Chemo-enzymatic synthesis of 3-O- (β-d-glycopyranosyl)-sn-glycerols and their evaluation as preservative in cosmetics - Université d'Orléans Accéder directement au contenu
Article Dans Une Revue Pure and Applied Chemistry Année : 2017

Chemo-enzymatic synthesis of 3-O- (β-d-glycopyranosyl)-sn-glycerols and their evaluation as preservative in cosmetics

Résumé

D-Glycopyranosyl glycerols are common natural products and exhibit strong biological properties, notably as moisturizing agents in cosmetics. Their chemical synthesis remains tedious thus decreasing their potential industrial and economic development, as well as the study of their structure-function relationships. In this work, the chemo-enzymatic synthesis of three enantiopure 3-O-(beta-D-glycopyranosyl)-sn-glycerols was efficiently performed using an original glycosidase from Dictyoglomus thermophilum and their preservatives properties were assessed using a challenge test method. Amongst them, the 3-O-(beta-D-glucopyranosyl)-snglycerol exhibited a specific anti-fungus activity.

Dates et versions

hal-01886425 , version 1 (02-10-2018)

Identifiants

Citer

Laure Guillotin, Perrine Cancellieri, Pierre Lafite, Ludovic Landemarre, Richard Daniellou. Chemo-enzymatic synthesis of 3-O- (β-d-glycopyranosyl)-sn-glycerols and their evaluation as preservative in cosmetics. Pure and Applied Chemistry, 2017, 89 (9), pp.1295-1304. ⟨10.1515/pac-2016-1210⟩. ⟨hal-01886425⟩
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