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Communication Dans Un Congrès Année : 2019

Plasma medicine: issues and challenges linked to the plasma/biological target interactions

Résumé

The biological applications of plasmas are currently experiencing an impressive boom. This leads to many diagnostic experiments to better assess the role of the different components of the plasma. Many of those are made on plasmas developing freely in the air, far from the conditions of use. However, the plasma/target interactions are of considerable importance as they lead to simultaneous changes in the produced plasma and the target. After a presentation of the context, we will address this issue and give some perspectives. The last decade has seen an impressive increase of the research dedicated to the biomedical applications of low temperature plasmas, especially with plasma sources working at atmospheric pressure. In this new trend, beside decontamination/sterilization and surface treatment that have already a quite long story through low-pressure plasma research and developments, medical applications are tacking an increasing place underlined by the actual numerous clinical trials. Medical applications of low temperature plasmas now concern a very wide range of domains, including primary haemostasis and blood coagulation, dental care, skin decontamination and hygiene, wound and ulcer treatment, dermatology, cancer treatment. Biological applications are also now extended to agriculture and, more recently, to cosmetic. Despite the huge number of in vitro and in vivo experiments there are still numerous challenges to overcome linked to the nature of the encountered target (biological tissues and materials, organs and their direct environment, liquids) that have a direct effect on the produced plasma itself and on the generated species. That must therefore be taken into account in the applied treatments and complicates the definition of a "plasma dose" expected by many. It appears also very important to always take into account the complete electric circuit represented by the plasma reactor, the plasma itself and the biological target, which electrical conductivity can vary over the time, to properly adjust the plasma parameters.
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Dates et versions

hal-02959327 , version 1 (08-12-2020)

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  • HAL Id : hal-02959327 , version 1

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Jean-Michel Pouvesle, Robert Eric. Plasma medicine: issues and challenges linked to the plasma/biological target interactions. 24th International Symposium on plasma chemistry (ISPC24), International Plasma Chemistry Society, Jun 2019, Naples, Italy. ⟨hal-02959327⟩
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