Modern Approaches to Synthetic Design of Chiral α-Tertiary Amines Based on Trifluoromethylcontaining Ketimines: A Review - Université d'Orléans Accéder directement au contenu
Article Dans Une Revue Theoretical and Experimental Chemistry Année : 2022

Modern Approaches to Synthetic Design of Chiral α-Tertiary Amines Based on Trifluoromethylcontaining Ketimines: A Review

Résumé

Enantioselective construction methods of chiral derivatives of α-tertiary amines using acyclic and cyclic trifluoromethylketimines are considered. The importance of a trifluoromethyl group in the structure of ketimine substrates for effective asymmetric addition of C-nucleophilic reagents in the presence of metal complex catalysts or organocatalysts is emphasized. The practical application of these chiral products in medicinal chemistry is covered.
Fichier non déposé

Dates et versions

hal-03888786 , version 1 (07-12-2022)

Identifiants

Citer

Volodymyr Sukach, V. Tkachuk, Isabelle Gillaizeau, Mykhailo Vovk. Modern Approaches to Synthetic Design of Chiral α-Tertiary Amines Based on Trifluoromethylcontaining Ketimines: A Review. Theoretical and Experimental Chemistry, 2022, 57 (6), pp.387-420. ⟨10.1007/s11237-022-09710-z⟩. ⟨hal-03888786⟩
17 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More